DESCRIPTION
The leukocyte histamine release test (LHRT) measures the amount of histamine released in-vitro. An allergen extract in varying concentrations is added to the peripheral blood leukocytes of the individual being tested. Histamine is normally released as a consequence of the interaction of allergen with cell-bound IgE antibodies. If an individual is hypersensitive to a specific antigen, the leukocytes will release the histamine in-vitro. Only a limited number of allergens can be tested from a single sample of blood. Quality control studies have shown variability in the measurement of histamine results.
POLICY
The leukocyte histamine release test in the diagnosis of allergies is considered investigational.
See also: General Policy for Allergy Testing and Treatment
ADDITIONAL INFORMATION
Clinical data supporting the role of leukocyte histamine release testing in the diagnosis of allergies is lacking.
SOURCES
BlueCross BlueShield Association. Medical Policy Reference Manual. (5:2006). Leukocyte histamine release test (2.04.42). Retrieved May 21, 2009 from BlueWeb.
Golbert, T. (1975). A review of controversial diagnostic and therapeutic techniques employed in allergy. Journal of Allergy and Clinical Immunology, 56 (3), 170 - 190.
Griese, M., Kusenbach, G., & Reinhardt, D. (1990). Histamine release test in comparison to standard tests in diagnosis of childhood allergic asthma. Annals of Allergy, 65(1), 46 - 51.
ORIGINAL EFFECTIVE DATE: 10/12/1998
MOST RECENT REVIEW DATE: 7/9/2009
ID_BA
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