Commonly Prescribed Anti-emetics for the Treatment
of Hyperemesis Gravidarum
AGENT |
IV |
IM |
PO |
PR |
SQ |
DOSAGE |
|
Doxylamine (Unisom) |
|
|
· |
|
|
25 mg PO HS or 12.5 mg PO BID |
|
Dimenhydrinate (Dramamine) |
· |
· |
· |
|
|
50-100 mg PO Q4H; 50 mg IV/IM
Q3-4H |
|
Diphenhydramine (Benadryl) |
· |
· |
· |
|
|
50 mg PO TID/QID; 25-50 mg IM/IV
Q2-3H |
|
Meclizine (Antivert) |
|
|
· |
|
|
20-50 mg PO QD |
|
Metoclopramide (Reglan) |
· |
· |
· |
|
· |
5-10 mg PO/IV/IM QID |
|
Chlorpromazine (Thorazine) |
· |
· |
· |
· |
|
10-25 mg PO Q4-6H |
|
Prochlorperazine (Compazine) |
· |
· |
· |
· |
|
5-10 mg PO/IM TID-QID; 10-25
mg PR Q4-6H |
|
Promethazine (Phenergan) |
· |
· |
· |
· |
|
12.5-25 mg IM/PO Q4-6H; 25 mg
PR Q4-6H |
|
Scopolamine Patch (Transderm
Scop) |
|
|
|
|
|
Transdermal Patch 1.5 mg: 1
patch applied Q1-3 days |
|
Trimethobenzamide (Tigan) |
|
· |
· |
|
|
250 mg PO Q6-8H;
100-200 mg IM Q6-8H |
Ondansetron
(Zofran) |
· |
· |
· |
|
|
Up
to 8 mg IV or PO every 6 hours, not to exceed 32 mg/day. |
Additional Information
The use of steroids (e.g., Decadron 4 mg IV, along with other antiemetics)
is being used post anesthesia to help control nausea.
SOURCES
BlueCross BlueShield of Tennessee network physicians. April - June 2008.
U. S. Food and Drug Administration. (2000, December). Center for Drug Evaluation and Research. Zofran®. Retrieved February 14, 2003 from http://www.fda.gov/cder/foi/nda/99/20781_Zofran.pdf.
U. S. Food and Drug Administration. (2007, April). Center for Drug Evaluation and Research. FDA announces that companies must stop marketing suppository products containing trimethobenzamide. Retrieved January 16, 2008 from http://www.fda.gov/bbs/topics/NEWS/2007/NEW01601.html. |
