Upcoming Medical Policies
BlueCross BlueShield of Tennessee

Each medical policy listed below will become effective on the date indicated, and will be included in the Medical Policy Manual for BlueCross BlueShield of Tennessee on that effective date.

Medical policies are developed using an evidence-based evaluation process. The medical evidence used in this process comes from several sources, including independent medical technology review organizations, the peer reviewed medical literature, and opinions from appropriate network specialists. All Medical Policies are reviewed by a panel of internal and external physicians before being adopted by the company.

Topics due to be included in the Medical Policy Manual on 08/30/2025

Topics due to be included in the Medical Policy Manual on 09/30/2025

Topics due to be included in the Medical Policy Manual on 10/31/2025

Topics due to be included in the Medical Policy Manual on 08/30/2025

Daratumumab (Darzalex®)

Daratumumab and hyaluronidase-fihj (Darzalex Faspro®)

Etranacogene Dezaparvovec-drlb (Hemgenix®)

Inclisiran (Leqvio®)

Infliximab Products: Infliximab (Remicade®); Infliximab axxq (Avsola™); Infliximab dyyb (Inflectra™); Infliximab abda (Renflexis™); Infliximab-dyyb (Zymfentra), infliximab

Isatuximab-irfc (Sarclisa®)

Nedosiran (Rivfloza™)

Negative Pressure Wound Therapy in the Outpatient Setting

Nivolumab/Relatlimab-rmbw (Opdualag™)

Octreotide Suspension (Sandostatin® LAR Depot), Octreotide Acetate for Injectable Suspension

Pharmacogenetic Testing for Pain Management

Prademagene Zamikeracel (Zevaskyn™)

Revakinagene Taroretcel-lwey (Encelto™)

Risankizumab-rzaa (Skyrizi®)

Talimogene Laherparepvec (Imlygic™)

Telisotuzumab vedotin-tllv (Emrelis™)

Ustekinumab Products

Topics due to be included in the Medical Policy Manual on 09/30/2025

Abraxane® (paclitaxel, albumin-bound) paclitaxel, albumin-bound

Alpha-1 Proteinase Inhibitor (Aralast NP®, Glassia®, Prolastin-C®, Zemaira®)

Anifrolumab-fnia (Saphnelo®)

Azacitidine (Vidaza®)

Belimumab (Benlysta®)

Beremagene Geperpavec-svdt (Vyjuvek™)

Canakinumab (Ilaris®)

Cipaglucosidase Alfa-atga (Pombiliti™)

Circulating Tumor DNA (Liquid Biopsy)

Complementary and Alternative Medicine

Durvalumab (Imfinzi®)

Elosulfase Alfa (Vimizim®)

Galsulfase (Naglazyme®)

Idursulfase (Elaprase®)

Imetelstat (Rytelo™)

Imiglucerase (Cerezyme®)

Laronidase (Aldurazyme®)

Pegcetacoplan (Syfovre™)

Pertuzumab (Perjeta®)

Pertuzumab, Trastuzumab and Hyaluronidase-zzxf (Phesgo™)

Romidepsin [Istodax®; Romidepsin (liquid)]

Sacituzumab Govitecan-hziy (Trodelvy®

Secukinumab (Cosentyx®)

Siltuximab (Sylvant™)

Taliglucerase Alfa (Elelyso®)

Temozolomide (Temodar®), temozolomide

Tildrakizumab-asmn (IIumya®)

Tocilizumab (Actemra®); Tocilizumab-anoh (Avtozma®); Tocilizumab-bavi (Tofidence™); Tocilizumab-aazg (Tyenne®)

Tremelimumab-actl (Imjudo®)

Velaglucerase Alfa (VPRIV®)

Vestronidase Alfa-vjbk (Mepsevii®)

Voretigene Neparvovec-rzyl (Luxturna®)

Medical policies to be Archived on 09/30/2025:

 Remdesivir (Veklury®) as an Outpatient Treatment of COVID-19 - Pharmacy plans to archive due to decreased utilization and broader clinical experience.

Topics due to be included in the Medical Policy Manual on 10/31/2025

AbobotulinumtoxinA (Dysport®)

Aflibercept Products

Atezolizumab (Tecentriq®)

Atezolizumab and Hyaluronidase-tqjs (Tecentriq Hybreza™)

Bevacizumab Products

Cemiplimab-rwlc (Libtayo®)

DaxibotulinumtoxinA-lanm (Daxxify™)

Delandistrogene moxeparvovec-rokl (Elevidys®)

Denosumab Products: (Prolia®)

Denosumab Products: (Xgeva®)

Eculizumab Products

Efgartigimod Alfa-fcab Products

Fam-trastuzumab Deruxtecan-nxki (Enhertu®)

Histrelin Acetate (Supprelin® LA)

IncobotulinumtoxinA (Xeomin®)

Inebilizumab-cdon (Uplizna™)

Infliximab Products

Ipilimumab (Yervoy®)

Intravenous Immune Globulin (IVIG)

Leuprolide Acetate (Fensolvi®)

Leuprolide Suspension (Lupron Depot-Ped®)

Nivolumab (Opdivo®)

Nivolumab and Hyaluronidase-nvhy (Opdivo Qvantig™)

Ocrelizumab (Ocrevus™) Ocrelizumab and Hyaluronidase-ocsq (Ocrevus Zunovo)

Omalizumab (Xolair®)

OnabotulinumtoxinA (Botox®

Pembrolizumab (Keytruda®)

Pertuzumab (Perjeta®)

RimabotulinumtoxinB (Myobloc®)

Treatment for Sexual Dysfunction in Males: Non-Pharmacologic

Triptorelin (Triptodur®)

Ustekinumab Products


Last Review Date: 8/14/2025

Medical Policy Comments:

Please reference the policy name in your comments.
To submit comments about the upcoming Medical policies:
Click the “Medical Policy Comments” above or click here: Comments or Feedback.

Pharmacy Policy Comments:

Please reference the policy name in your comments.
To submit comments about the upcoming Pharmacy policies:
Click the “Pharmacy Policy Comments” above or click here: Comments or Feedback.

Comments can also be mailed to:

BlueCross BlueShield of Tennessee
Medical Policy
1 Cameron Hill Circle
Chattanooga, TN 37402