BlueCross BlueShield of Tennessee Medical Policy Manual

Gene Expression Testing for Coronary Artery Disease

Does Not Apply to Commercial Genetic Testing Program effective 6/1/2018


Obstructive coronary artery disease (CAD) in individuals with stable chest pain is typically evaluated by stress echocardiography, myocardial perfusion imaging, and computed tomography angiography. Corus CAD™, developed by CardioDX®, Inc., is a genomic test designed for use in an outpatient setting with clinically stable, non-diabetic individuals who present with chest pain or who have a high risk of coronary artery disease but do not have a previously diagnosed myocardial infarction or prior revascularization procedure. Test results are provided as a numeric score that quantifies the likelihood that the individual with stable chest pain has obstructive CAD.




There is a lack of available evidence to determine the clinical importance of this test over standard, accepted testing methods and for use in predicting clinical events or altering treatment.


American Heart Association. (2012). Genetics and cardiovascular disease. A policy statement from the American Heart Association. Retrieved September 6, 2017 from

American Heart Association. (2017). The expressed genome in cardiovascular diseases and stroke: refinement, diagnosis, and prediction: a scientific statement from the American Heart Association. Retrieved November 10, 2017 from

BlueCross BlueShield Association. Evidence Positioning System. (4:2019). Gene expression testing in the evaluation of patients with stable ischemic heart disease (2.04.72). Retrieved September 5, 2019 from (29 articles and/or guidelines reviewed)

Daniels, S. E., Beineke, P., Rhees, B., McPherson, J. A., Kraus, W. E., Thomas, G. S., et al. (2014). Biological and analytical stability of a peripheral blood gene expression score for obstructive coronary artery disease in the PREDICT and COMPASS studies. Journal of Cardiovascular Translational Research, 7 (7), 616-622. (Level 2 evidence)

Filsoof, D. M., Safford, R. E., Newby, K. Rosenberg, S., Kontras, D. G., Baker, A., et al. (2015). Impact of exercise stress testing on diagnostic gene expression in patients with obstructive and nonobstructive coronary artery disease. American Journal of Cardiology, 115 (10), 1346-1350. Abstract retrieved November 6, 2015 from PubMed database.

Gul, B., Lansky, A., Budoff, M., Sharp, D., Maniet, B., Herman, L., Kuo, J., et al. (2019). The clinical utility of a precision medicine blood test incorporating age, sex, and gene expression for evaluating women with stable symptoms suggestive of obstructive coronary artery disease: analysis from the PRESET registry. Journal of Women’s Health, 28 (5), 728-735. (Level 2 evidence)

Ladapo, J. A., Herman, L., Weiner, B. H., Rhees, B., Castle, L., Monane, M., et al. (2015). Use of a blood test incorporating age, sex and gene expression influences medical decision-making in the evaluation of women presenting with symptoms suggestive of obstructive coronary artery disease: summary results from two ambulatory care studies in primary care. Menopause: The Journal of the North American Menopause Society, 22 (11), 1-7. (Level 2 evidence)

Ladapo, J. A., Lyons, H., Yau, M., Rich, P., Newton, D., Bruce-Mensah, K., et al. (2014). Enhanced assessment of chest pain and related symptoms in the primary care setting through the use of a novel personalized medicine genomic test. American Journal of Medical Quality, 30 (4), 345-352. (Level 2 evidence)

Ladapo, J.A., Budoff, M.J., Sharp, D., Kuo, J., Huang, L., Maniet, B., et al. (2017). Utility of a precision medicine test in elderly adults with symptoms suggestive of coronary artery disease. Journal of the American Geriatric Society, 66 (2), 309-315. (Level 3 evidence)

Voora, D., Coles, A., Lee, K.L., Hoffmann, U., Wingrove, J.A., Rhees, B., et al. (2017). An age- and sex- specific gene expression score is associated with revascularization and coronary artery disease: insights from the prospective multicenter imaging study for evaluation of chest pain (PROMISE) trial. American Heart Journal, 184, 133-140. Abstract retrieved September 5, 2019 from PubMed database.


MOST RECENT REVIEW DATE:  10/10/2019    


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